CKE is used when switching between ranks (you are using more ranks if you have more memory chips connected to the same data signals e.g. you have two memory chips connected to D0) and also to control some memory modes. So, if you are using ranks, you definitely need to control CKE. If you a re using single rank memory, I am not sure if you could simply keep CKE active all the time and if yes, what would be the impact to power consumption. If you are using CKE, it needs to be in relationship with CLK, so it is important how it is routed and length matched.
This is from
https://www.altera.co.jp/ja_JP/pdfs/..._dual_ddr2.pdf"The control group signals (chip Select CS#, clock enable CKE, and ODT) are only ever single rank. A dual-rank capable DDR3 DIMM slot has two copies of each signal, and a dual-DIMM slot interface has four copies of each signal. The signal quality of these signals is identical to a single rank case. The control group of signals, are always 1T regardless of whether you implement a full-rate or half-rate design. As the signals are also SDR, the control group signals operate at a maximum frequency of 0.5 × the data rate. For example, in a 400 MHz design, the maximum control group frequency is 200 MHz"